B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation

B cells contribute to rheumatoid arthritis pathogenesis and bone erosion, but the underlying mechanisms are still unclear. Here the authors show, using mouse models and patient tissues, that B cells directly inhibit osteoblast differentiation by producing CCL3 and TNF, thereby providing a potentiall...

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Autores principales:	Wen Sun, Nida Meednu, Alexander Rosenberg, Javier Rangel-Moreno, Victor Wang, Jason Glanzman, Teresa Owen, Xichao Zhou, Hengwei Zhang, Brendan F. Boyce, Jennifer H. Anolik, Lianping Xing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/879bcc165f4342d5914461b4c9efd208
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spelling	oai:doaj.org-article:879bcc165f4342d5914461b4c9efd2082021-12-02T17:31:13ZB cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation10.1038/s41467-018-07626-82041-1723https://doaj.org/article/879bcc165f4342d5914461b4c9efd2082018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07626-8https://doaj.org/toc/2041-1723B cells contribute to rheumatoid arthritis pathogenesis and bone erosion, but the underlying mechanisms are still unclear. Here the authors show, using mouse models and patient tissues, that B cells directly inhibit osteoblast differentiation by producing CCL3 and TNF, thereby providing a potentially new direction for arthritis therapy.Wen SunNida MeednuAlexander RosenbergJavier Rangel-MorenoVictor WangJason GlanzmanTeresa OwenXichao ZhouHengwei ZhangBrendan F. BoyceJennifer H. AnolikLianping XingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen Sun Nida Meednu Alexander Rosenberg Javier Rangel-Moreno Victor Wang Jason Glanzman Teresa Owen Xichao Zhou Hengwei Zhang Brendan F. Boyce Jennifer H. Anolik Lianping Xing B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
description	B cells contribute to rheumatoid arthritis pathogenesis and bone erosion, but the underlying mechanisms are still unclear. Here the authors show, using mouse models and patient tissues, that B cells directly inhibit osteoblast differentiation by producing CCL3 and TNF, thereby providing a potentially new direction for arthritis therapy.
format	article
author	Wen Sun Nida Meednu Alexander Rosenberg Javier Rangel-Moreno Victor Wang Jason Glanzman Teresa Owen Xichao Zhou Hengwei Zhang Brendan F. Boyce Jennifer H. Anolik Lianping Xing
author_facet	Wen Sun Nida Meednu Alexander Rosenberg Javier Rangel-Moreno Victor Wang Jason Glanzman Teresa Owen Xichao Zhou Hengwei Zhang Brendan F. Boyce Jennifer H. Anolik Lianping Xing
author_sort	Wen Sun
title	B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
title_short	B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
title_full	B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
title_fullStr	B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
title_full_unstemmed	B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
title_sort	b cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/879bcc165f4342d5914461b4c9efd208
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B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation

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