Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma
Patient-derived xenografts provide a resource for basic and translational cancer research. Here, the authors generate multiple pediatric high-grade glioma xenografts, use omics technologies to show that they are representative of primary tumours and use them to assess therapeutic response.
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Nature Portfolio
2021
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oai:doaj.org-article:879be8929790465bbe548678fef6db022021-12-02T14:34:06ZPatient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma10.1038/s41467-021-24168-82041-1723https://doaj.org/article/879be8929790465bbe548678fef6db022021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24168-8https://doaj.org/toc/2041-1723Patient-derived xenografts provide a resource for basic and translational cancer research. Here, the authors generate multiple pediatric high-grade glioma xenografts, use omics technologies to show that they are representative of primary tumours and use them to assess therapeutic response.Chen HeKe XuXiaoyan ZhuPaige S. DunphyBrian GudenasWenwei LinNathaniel TwarogLaura D. HoverChang-Hyuk KwonLawryn H. KasperJunyuan ZhangXiaoyu LiJames DaltonBarbara JonchereKimberly S. MercerDuane G. CurrierWilliam CaufieldYingzhe WangJia XieAlberto BroniscerCynthia WetmoreSanthosh A. UpadhyayaIbrahim QaddoumiPaul KlimoFrederick BoopAmar GajjarJinghui ZhangBrent A. OrrGiles W. RobinsonMichelle MonjeBurgess B. Freeman IIIMartine F. RousselPaul A. NorthcottTaosheng ChenZoran RankovicGang WuJason ChiangChristopher L. TinkleAnang A. ShelatSuzanne J. BakerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chen He Ke Xu Xiaoyan Zhu Paige S. Dunphy Brian Gudenas Wenwei Lin Nathaniel Twarog Laura D. Hover Chang-Hyuk Kwon Lawryn H. Kasper Junyuan Zhang Xiaoyu Li James Dalton Barbara Jonchere Kimberly S. Mercer Duane G. Currier William Caufield Yingzhe Wang Jia Xie Alberto Broniscer Cynthia Wetmore Santhosh A. Upadhyaya Ibrahim Qaddoumi Paul Klimo Frederick Boop Amar Gajjar Jinghui Zhang Brent A. Orr Giles W. Robinson Michelle Monje Burgess B. Freeman III Martine F. Roussel Paul A. Northcott Taosheng Chen Zoran Rankovic Gang Wu Jason Chiang Christopher L. Tinkle Anang A. Shelat Suzanne J. Baker Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma |
| description |
Patient-derived xenografts provide a resource for basic and translational cancer research. Here, the authors generate multiple pediatric high-grade glioma xenografts, use omics technologies to show that they are representative of primary tumours and use them to assess therapeutic response. |
| format |
article |
| author |
Chen He Ke Xu Xiaoyan Zhu Paige S. Dunphy Brian Gudenas Wenwei Lin Nathaniel Twarog Laura D. Hover Chang-Hyuk Kwon Lawryn H. Kasper Junyuan Zhang Xiaoyu Li James Dalton Barbara Jonchere Kimberly S. Mercer Duane G. Currier William Caufield Yingzhe Wang Jia Xie Alberto Broniscer Cynthia Wetmore Santhosh A. Upadhyaya Ibrahim Qaddoumi Paul Klimo Frederick Boop Amar Gajjar Jinghui Zhang Brent A. Orr Giles W. Robinson Michelle Monje Burgess B. Freeman III Martine F. Roussel Paul A. Northcott Taosheng Chen Zoran Rankovic Gang Wu Jason Chiang Christopher L. Tinkle Anang A. Shelat Suzanne J. Baker |
| author_facet |
Chen He Ke Xu Xiaoyan Zhu Paige S. Dunphy Brian Gudenas Wenwei Lin Nathaniel Twarog Laura D. Hover Chang-Hyuk Kwon Lawryn H. Kasper Junyuan Zhang Xiaoyu Li James Dalton Barbara Jonchere Kimberly S. Mercer Duane G. Currier William Caufield Yingzhe Wang Jia Xie Alberto Broniscer Cynthia Wetmore Santhosh A. Upadhyaya Ibrahim Qaddoumi Paul Klimo Frederick Boop Amar Gajjar Jinghui Zhang Brent A. Orr Giles W. Robinson Michelle Monje Burgess B. Freeman III Martine F. Roussel Paul A. Northcott Taosheng Chen Zoran Rankovic Gang Wu Jason Chiang Christopher L. Tinkle Anang A. Shelat Suzanne J. Baker |
| author_sort |
Chen He |
| title |
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma |
| title_short |
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma |
| title_full |
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma |
| title_fullStr |
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma |
| title_full_unstemmed |
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma |
| title_sort |
patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/879be8929790465bbe548678fef6db02 |
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