Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38α kinase.
The vast majority of small molecules known to modulate kinase activity, target the highly conserved ATP-pocket. Consequently, such ligands are often less specific and in case of inhibitors, this leads to the inhibition of multiple kinases. Thus, selective modulation of kinase function remains a majo...
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Autores principales: | Matthäus Getlik, Jeffrey R Simard, Martin Termathe, Christian Grütter, Matthias Rabiller, Willem A L van Otterlo, Daniel Rauh |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/87ccca3039fb4ca1a25928d702a9a1d7 |
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