Zebrafish Adar2 Edits the Q/R site of AMPA receptor Subunit gria2α transcript to ensure normal development of nervous system and cranial neural crest cells.

Zebrafish Adar2 Edits the Q/R site of AMPA receptor Subunit gria2α transcript to ensure normal development of nervous system and cranial neural crest cells.

<h4>Background</h4>Adar2 deaminates selective adenosines to inosines (A-to-I RNA editing) in the double-stranded region of nuclear transcripts. Although the functions of mouse Adar2 and its biologically most important substrate gria2, encoding the GluA2 subunit of AMPA (α-amino-3-hydroxy...

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Main Authors: I-Chen Li, Yu-Chia Chen, Yi-Yun Wang, Bo-Wei Tzeng, Chun-Wen Ou, Yi-Yan Lau, Kan-Mai Wu, Tzu-Min Chan, Wei-Hsiang Lin, Sheng-Ping L Hwang, Wei-Yuan Chow
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/8813560b52d1483b97f11bc8a2a74f44
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