Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex

Abstract Serine proteases catalyze a multi-step covalent catalytic mechanism of peptide bond cleavage. It has long been assumed that serine proteases including thrombin carry-out catalysis without significant conformational rearrangement of their stable two-β-barrel structure. We present nuclear mag...

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Autores principales: Riley B. Peacock, Taylor McGrann, Marco Tonelli, Elizabeth A. Komives
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/88183b8ffe2e4f00a14e25f6f59fd4a8
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