Theoretical principles of transcription factor traffic on folded chromatin

How transcription factors find their targets in vivo is still poorly understood. Here the authors use molecular dynamics simulations to investigate how transcription factors diffuse on chromatin, providing a theoretical framework for understanding the key role of genome conformation in this process.

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Detalles Bibliográficos
Autores principales:	Ruggero Cortini, Guillaume J. Filion
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8818853b5c76420db353655d10fd7053
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spelling	oai:doaj.org-article:8818853b5c76420db353655d10fd70532021-12-02T14:40:02ZTheoretical principles of transcription factor traffic on folded chromatin10.1038/s41467-018-04130-x2041-1723https://doaj.org/article/8818853b5c76420db353655d10fd70532018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04130-xhttps://doaj.org/toc/2041-1723How transcription factors find their targets in vivo is still poorly understood. Here the authors use molecular dynamics simulations to investigate how transcription factors diffuse on chromatin, providing a theoretical framework for understanding the key role of genome conformation in this process.Ruggero CortiniGuillaume J. FilionNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruggero Cortini Guillaume J. Filion Theoretical principles of transcription factor traffic on folded chromatin
description	How transcription factors find their targets in vivo is still poorly understood. Here the authors use molecular dynamics simulations to investigate how transcription factors diffuse on chromatin, providing a theoretical framework for understanding the key role of genome conformation in this process.
format	article
author	Ruggero Cortini Guillaume J. Filion
author_facet	Ruggero Cortini Guillaume J. Filion
author_sort	Ruggero Cortini
title	Theoretical principles of transcription factor traffic on folded chromatin
title_short	Theoretical principles of transcription factor traffic on folded chromatin
title_full	Theoretical principles of transcription factor traffic on folded chromatin
title_fullStr	Theoretical principles of transcription factor traffic on folded chromatin
title_full_unstemmed	Theoretical principles of transcription factor traffic on folded chromatin
title_sort	theoretical principles of transcription factor traffic on folded chromatin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8818853b5c76420db353655d10fd7053
work_keys_str_mv	AT ruggerocortini theoreticalprinciplesoftranscriptionfactortrafficonfoldedchromatin AT guillaumejfilion theoreticalprinciplesoftranscriptionfactortrafficonfoldedchromatin
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Theoretical principles of transcription factor traffic on folded chromatin

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