Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer

Tumours are made up of heterogeneous subclones. Here, the authors show using breast cancer imaging and gene expression datasets that these subclones can be inferred by the deconvolution of gene expression data, mapped to MRI derived radiogenomic signatures and used to estimate prognosis.

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Bibliographic Details
Main Authors:	Ming Fan, Pingping Xia, Robert Clarke, Yue Wang, Lihua Li
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/881d41ad02f34b639dffa6a53f36c8c9
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id	oai:doaj.org-article:881d41ad02f34b639dffa6a53f36c8c9
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spelling	oai:doaj.org-article:881d41ad02f34b639dffa6a53f36c8c92021-12-02T18:14:41ZRadiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer10.1038/s41467-020-18703-22041-1723https://doaj.org/article/881d41ad02f34b639dffa6a53f36c8c92020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18703-2https://doaj.org/toc/2041-1723Tumours are made up of heterogeneous subclones. Here, the authors show using breast cancer imaging and gene expression datasets that these subclones can be inferred by the deconvolution of gene expression data, mapped to MRI derived radiogenomic signatures and used to estimate prognosis.Ming FanPingping XiaRobert ClarkeYue WangLihua LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming Fan Pingping Xia Robert Clarke Yue Wang Lihua Li Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer
description	Tumours are made up of heterogeneous subclones. Here, the authors show using breast cancer imaging and gene expression datasets that these subclones can be inferred by the deconvolution of gene expression data, mapped to MRI derived radiogenomic signatures and used to estimate prognosis.
format	article
author	Ming Fan Pingping Xia Robert Clarke Yue Wang Lihua Li
author_facet	Ming Fan Pingping Xia Robert Clarke Yue Wang Lihua Li
author_sort	Ming Fan
title	Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer
title_short	Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer
title_full	Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer
title_fullStr	Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer
title_full_unstemmed	Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer
title_sort	radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/881d41ad02f34b639dffa6a53f36c8c9
work_keys_str_mv	AT mingfan radiogenomicsignaturesrevealmultiscaleintratumourheterogeneityassociatedwithbiologicalfunctionsandsurvivalinbreastcancer AT pingpingxia radiogenomicsignaturesrevealmultiscaleintratumourheterogeneityassociatedwithbiologicalfunctionsandsurvivalinbreastcancer AT robertclarke radiogenomicsignaturesrevealmultiscaleintratumourheterogeneityassociatedwithbiologicalfunctionsandsurvivalinbreastcancer AT yuewang radiogenomicsignaturesrevealmultiscaleintratumourheterogeneityassociatedwithbiologicalfunctionsandsurvivalinbreastcancer AT lihuali radiogenomicsignaturesrevealmultiscaleintratumourheterogeneityassociatedwithbiologicalfunctionsandsurvivalinbreastcancer
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Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer

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