TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

Engagement of T cell receptors (TCRs) induces the formation of microclusters that mediate the downstream signalling events. Here the authors show, using high resolution TIRF-SIM and live cell imaging, that ZAP70 and LAT are recruited to TCR with distinct kinetics, with the delayed ZAP70-TCR associat...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jason Yi, Lakshmi Balagopalan, Tiffany Nguyen, Katherine M. McIntire, Lawrence E. Samelson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/886499537f5d4d8a84ce8c1d223bc7f0
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!