Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release

Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release

ABSTRACT Hepatitis C virus (HCV) spreads via secreted cell-free particles or direct cell-to-cell transmission. Yet, virus-host determinants governing differential intracellular trafficking of cell-free- and cell-to-cell-transmitted virus remain unknown. The host adaptor proteins (APs) AP-1A, AP-1B,...

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Bibliographic Details
Main Authors: Fei Xiao, Stanley Wang, Rina Barouch-Bentov, Gregory Neveu, Szuyuan Pu, Melanie Beer, Stanford Schor, Sathish Kumar, Vlad Nicolaescu, Brett D. Lindenbach, Glenn Randall, Shirit Einav
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
adaptor proteins
antiviral strategies
cell-to-cell spread
hepatitis C virus
intracellular membrane trafficking
viral release
Microbiology
QR1-502
Online Access:https://doaj.org/article/887b3dbf4a214050b6ab36a669811582
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https://doaj.org/article/887b3dbf4a214050b6ab36a669811582

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