Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

QR Code

Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

ABSTRACT Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response. Deletion of NS1 (DelNS1) would create a safer and more extensively immunogenic live attenuated influenza virus (LAIV)...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Pui Wang, Min Zheng, Siu-Ying Lau, Pin Chen, Bobo Wing-Yee Mok, Siwen Liu, Honglian Liu, Xiaofeng Huang, Conor J. Cremin, Wenjun Song, Yixin Chen, Yik-Chun Wong, Haode Huang, Kelvin Kai-Wong To, Zhiwei Chen, Ningshao Xia, Kwok-Yung Yuen, Honglin Chen
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2019
Sujets:	live attenuated vaccine NS1 influenza vaccines Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/8881e0d1dc374c51a365ffa1af2aebdd
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Inmunogenicidad y reactogenicidad de una vacuna de difteria, tétanos, pertussis acelular de contenido antigénico reducido (dTpa) en niños de 10 a 11 años de edad y en adultos
par: Abarca V,Katia, et autres
Publié: (2002)

A Host-Restricted Self-Attenuated Influenza Virus Provides Broad Pan-Influenza A Protection in a Mouse Model
par: Minjin Kim, et autres
Publié: (2021)

Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain
par: Loulieta Nazerai, et autres
Publié: (2021)

An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
par: Xiaofeng Huang, et autres
Publié: (2017)

Immunogenicity and protective efficacy of prime-boost immunization in mice vaccinated with live and inactivated influenza A (H5N1) vaccines
par: I. Losev, et autres
Publié: (2019)

Influenza Vaccination Programs for Healthcare Personnel: Organizational Issues and Beyond
par: Helena C. Maltezou, et autres
Publié: (2021)

Targets and strategies for vaccine development against dengue viruses
par: Wen-Hung Wang, et autres
Publié: (2021)

Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication
par: Yen-Chin Liu, et autres
Publié: (2021)

Recent Progress in <i>Shigella</i> and <i>Burkholderia pseudomallei</i> Vaccines
par: Itziar Chapartegui-González, et autres
Publié: (2021)

Nasal spray live attenuated influenza vaccine: the first experience in Italy in children and adolescents during the 2020–21 season
par: Chiara Gasparini, et autres
Publié: (2021)

Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex
par: Emily H. Davis, et autres
Publié: (2019)

Updates on Dengue Vaccine and Antiviral: Where Are We Heading?
par: Harun Norshidah, et autres
Publié: (2021)

Factors Associated with Attitudes towards Seasonal Influenza Vaccination in Poland: A Nationwide Cross-Sectional Survey in 2020
par: Piotr Samel-Kowalik, et autres
Publié: (2021)

Patients’ Perception and Knowledge about Influenza and Pneumococcal Vaccination during the COVID-19 Pandemic: An Online Survey in Patients at Risk of Infections
par: Paul Loubet, et autres
Publié: (2021)

Influenza: Profilaxis mediante la inmunización activa
par: FICA C.,ALBERTO
Publié: (2001)

Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein
par: Grant Beyleveld, et autres
Publié: (2018)

IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN
par: M. P. Kostinov, et autres
Publié: (2017)

How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
par: Laurie-Anne Lamotte, et autres
Publié: (2021)

Public Interest in Distribution and Determinants of Influenza and Pneumonia Vaccination during the COVID-19 Pandemic: An Infodemiology and Cross-Sectional Study from China
par: Liubing Gong, et autres
Publié: (2021)

A Population-Based Propensity Score-Matched Study to Assess the Impact of Repeated Vaccination on Vaccine Effectiveness for Influenza-Associated Hospitalization Among the Elderly
par: Hsu PS, et autres
Publié: (2020)

NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?
par: Florian Krammer, et autres
Publié: (2018)

Heterosubtypic Protection Induced by a Live Attenuated Influenza Virus Vaccine Expressing Galactose-α-1,3-Galactose Epitopes in Infected Cells
par: Li-Meng Yan, et autres
Publié: (2020)

Next-Generation Computationally Designed Influenza Hemagglutinin Vaccines Protect against H5Nx Virus Infections
par: Ivette A. Nuñez, et autres
Publié: (2021)

Risk Of Urticaria In Geriatric Stroke Patients Who Received Influenza Vaccination: A Retrospective Cohort Study
par: Lam F, et autres
Publié: (2019)

The Usage of Influenza Vaccine to Prevent Seasonal Influenza during Pandemic COVID-19
par: Yelvi Levani, et autres
Publié: (2021)

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine
par: Rebecca Webster, et autres
Publié: (2021)

Deciphering the Molecular Basis for Attenuation of <i>Flavobacterium columnare</i> Strain Fc1723 Used as Modified Live Vaccine against Columnaris Disease
par: Wenlong Cai, et autres
Publié: (2021)

Improving Our Understanding of <italic toggle="yes">Salmonella enterica</italic> Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain
par: Ellen E. Higginson, et autres
Publié: (2018)

First report on molecular docking analysis and drug resistance substitutions to approved HCV NS5A and NS5B inhibitors amongst Iranian patients
par: Zahra Hasanshahi, et autres
Publié: (2021)

Simultaneous Infection With Porcine Reproductive and Respiratory Syndrome and Influenza Viruses Abrogates Clinical Protection Induced by Live Attenuated Porcine Reproductive and Respiratory Syndrome Vaccination
par: Tiphany Chrun, et autres
Publié: (2021)

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles
par: Christopher H. Lee, et autres
Publié: (2021)

COVID-19 Vaccine Hesitancy in a City with Free Choice and Sufficient Doses
par: Martin C. S. Wong, et autres
Publié: (2021)

Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine
par: Yinyan Yin, et autres
Publié: (2021)

Characteristics and Pathogenicity of the Cell-Adapted Attenuated Porcine Epidemic Diarrhea Virus of the Non-S INDEL Cluster
par: Thi Thu Hang Vu, et autres
Publié: (2021)

Synergistic Internal Ribosome Entry Site/MicroRNA-Based Approach for Flavivirus Attenuation and Live Vaccine Development
par: Konstantin A. Tsetsarkin, et autres
Publié: (2017)

Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses
par: Natalie D. Collins, et autres
Publié: (2018)

COVID-19 and Historic Influenza Vaccinations in the United States: A Comparative Analysis
par: Pranav Mirpuri, et autres
Publié: (2021)

Prescripción de la vacuna anti influenza por médicos institucionales y estudiantes de especialidades médicas en un hospital docente
par: FICA C,ALBERTO, et autres
Publié: (2001)

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages
par: Kizzmekia S. Corbett, et autres
Publié: (2019)

Vaccine
Publié: (1983)