Flexible experimental designs for valid single-cell RNA-sequencing experiments allowing batch effects correction

It is not clear which designs, other than completely randomized ones, are valid for scRNA-seq experiments so that batch effects can be adjusted. Here the authors show that under flexible reference panel and chain-type designs, biological variability can also be separated from batch effects, at least...

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Autores principales: Fangda Song, Ga Ming Angus Chan, Yingying Wei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/889067254b4d4524ba0685f276a62942
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