Roles of Macrophages in Atherogenesis

Atherosclerosis is a chronic inflammatory disease that may ultimately lead to local proteolysis, plaque rupture, and thrombotic vascular disease, resulting in myocardial infarction, stroke, and sudden cardiac death. Circulating monocytes are recruited to the arterial wall in response to inflammatory...

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Auteurs principaux:	Lia Farahi, Satyesh K. Sinha, Aldons J. Lusis
Format:	article
Langue:	EN
Publié:	Frontiers Media S.A. 2021
Sujets:	atherosclerosis inflammation macrophages lipid plaque biomarker Therapeutics. Pharmacology RM1-950
Accès en ligne:	https://doaj.org/article/88a00ed9d99249d8b04a5f17c7f94f37
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id	oai:doaj.org-article:88a00ed9d99249d8b04a5f17c7f94f37
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spelling	oai:doaj.org-article:88a00ed9d99249d8b04a5f17c7f94f372021-12-01T05:36:29ZRoles of Macrophages in Atherogenesis1663-981210.3389/fphar.2021.785220https://doaj.org/article/88a00ed9d99249d8b04a5f17c7f94f372021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.785220/fullhttps://doaj.org/toc/1663-9812Atherosclerosis is a chronic inflammatory disease that may ultimately lead to local proteolysis, plaque rupture, and thrombotic vascular disease, resulting in myocardial infarction, stroke, and sudden cardiac death. Circulating monocytes are recruited to the arterial wall in response to inflammatory insults and differentiate into macrophages which make a critical contribution to tissue damage, wound healing, and also regression of atherosclerotic lesions. Within plaques, macrophages take up aggregated lipoproteins which have entered the vessel wall to give rise to cholesterol-engorged foam cells. Also, the macrophage phenotype is influenced by various stimuli which affect their polarization, efferocytosis, proliferation, and apoptosis. The heterogeneity of macrophages in lesions has recently been addressed by single-cell sequencing techniques. This article reviews recent advances regarding the roles of macrophages in different stages of disease pathogenesis from initiation to advanced atherosclerosis. Macrophage-based therapies for atherosclerosis management are also described.Lia FarahiSatyesh K. SinhaAldons J. LusisFrontiers Media S.A.articleatherosclerosisinflammationmacrophageslipidplaquebiomarkerTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis inflammation macrophages lipid plaque biomarker Therapeutics. Pharmacology RM1-950
spellingShingle	atherosclerosis inflammation macrophages lipid plaque biomarker Therapeutics. Pharmacology RM1-950 Lia Farahi Satyesh K. Sinha Aldons J. Lusis Roles of Macrophages in Atherogenesis
description	Atherosclerosis is a chronic inflammatory disease that may ultimately lead to local proteolysis, plaque rupture, and thrombotic vascular disease, resulting in myocardial infarction, stroke, and sudden cardiac death. Circulating monocytes are recruited to the arterial wall in response to inflammatory insults and differentiate into macrophages which make a critical contribution to tissue damage, wound healing, and also regression of atherosclerotic lesions. Within plaques, macrophages take up aggregated lipoproteins which have entered the vessel wall to give rise to cholesterol-engorged foam cells. Also, the macrophage phenotype is influenced by various stimuli which affect their polarization, efferocytosis, proliferation, and apoptosis. The heterogeneity of macrophages in lesions has recently been addressed by single-cell sequencing techniques. This article reviews recent advances regarding the roles of macrophages in different stages of disease pathogenesis from initiation to advanced atherosclerosis. Macrophage-based therapies for atherosclerosis management are also described.
format	article
author	Lia Farahi Satyesh K. Sinha Aldons J. Lusis
author_facet	Lia Farahi Satyesh K. Sinha Aldons J. Lusis
author_sort	Lia Farahi
title	Roles of Macrophages in Atherogenesis
title_short	Roles of Macrophages in Atherogenesis
title_full	Roles of Macrophages in Atherogenesis
title_fullStr	Roles of Macrophages in Atherogenesis
title_full_unstemmed	Roles of Macrophages in Atherogenesis
title_sort	roles of macrophages in atherogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/88a00ed9d99249d8b04a5f17c7f94f37
work_keys_str_mv	AT liafarahi rolesofmacrophagesinatherogenesis AT satyeshksinha rolesofmacrophagesinatherogenesis AT aldonsjlusis rolesofmacrophagesinatherogenesis
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Roles of Macrophages in Atherogenesis

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