Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo

While immunotherapy is a promising cancer treatment option, durable benefits are often rare due to immune escape. Here, the authors combine epigenetic regulation with gene therapy-mediated immune checkpoint blockade and show efficient anti-tumour effects and immune response in vivo.

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Bibliographic Details
Main Authors:	Huapan Fang, Zhaopei Guo, Jie Chen, Lin Lin, Yingying Hu, Yanhui Li, Huayu Tian, Xuesi Chen
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/88a68866c470414a9fb6c60275bc712b
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spelling	oai:doaj.org-article:88a68866c470414a9fb6c60275bc712b2021-11-21T12:34:01ZCombination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo10.1038/s41467-021-27078-x2041-1723https://doaj.org/article/88a68866c470414a9fb6c60275bc712b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27078-xhttps://doaj.org/toc/2041-1723While immunotherapy is a promising cancer treatment option, durable benefits are often rare due to immune escape. Here, the authors combine epigenetic regulation with gene therapy-mediated immune checkpoint blockade and show efficient anti-tumour effects and immune response in vivo.Huapan FangZhaopei GuoJie ChenLin LinYingying HuYanhui LiHuayu TianXuesi ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huapan Fang Zhaopei Guo Jie Chen Lin Lin Yingying Hu Yanhui Li Huayu Tian Xuesi Chen Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo
description	While immunotherapy is a promising cancer treatment option, durable benefits are often rare due to immune escape. Here, the authors combine epigenetic regulation with gene therapy-mediated immune checkpoint blockade and show efficient anti-tumour effects and immune response in vivo.
format	article
author	Huapan Fang Zhaopei Guo Jie Chen Lin Lin Yingying Hu Yanhui Li Huayu Tian Xuesi Chen
author_facet	Huapan Fang Zhaopei Guo Jie Chen Lin Lin Yingying Hu Yanhui Li Huayu Tian Xuesi Chen
author_sort	Huapan Fang
title	Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo
title_short	Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo
title_full	Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo
title_fullStr	Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo
title_full_unstemmed	Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo
title_sort	combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88a68866c470414a9fb6c60275bc712b
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Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo

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