Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases

Metastatic melanoma is associated with a poor prognosis and understanding the genetic features of metastases may enable better treatment strategies. Here, the authors analyse multiple metastases from individual patients finding high levels of heterogeneity in metastases from different organs.

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Detalles Bibliográficos
Autores principales:	Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J. Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M. Martínez Gómez, Mitchell Levesque, Ferdia A. Gallagher, Alejandro Jiménez-Sánchez, Laura Riva, Martin L. Miller, Kieren Allinson, Peter J. Campbell, Pippa Corrie, David C. Wedge, David J. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88af25cb99664cab9677a9f33b3cdf38
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spelling	oai:doaj.org-article:88af25cb99664cab9677a9f33b3cdf382021-12-02T19:02:28ZMulti-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases10.1038/s41467-020-18060-02041-1723https://doaj.org/article/88af25cb99664cab9677a9f33b3cdf382020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18060-0https://doaj.org/toc/2041-1723Metastatic melanoma is associated with a poor prognosis and understanding the genetic features of metastases may enable better treatment strategies. Here, the authors analyse multiple metastases from individual patients finding high levels of heterogeneity in metastases from different organs.Roy RabbieNaser Ansari-PourOliver CastDoreen LauFrancis ScottSarah J. WelshChristine ParkinsonLeila KhojaLuiza MooreMark TullettKim WongIngrid FerreiraJulia M. Martínez GómezMitchell LevesqueFerdia A. GallagherAlejandro Jiménez-SánchezLaura RivaMartin L. MillerKieren AllinsonPeter J. CampbellPippa CorrieDavid C. WedgeDavid J. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roy Rabbie Naser Ansari-Pour Oliver Cast Doreen Lau Francis Scott Sarah J. Welsh Christine Parkinson Leila Khoja Luiza Moore Mark Tullett Kim Wong Ingrid Ferreira Julia M. Martínez Gómez Mitchell Levesque Ferdia A. Gallagher Alejandro Jiménez-Sánchez Laura Riva Martin L. Miller Kieren Allinson Peter J. Campbell Pippa Corrie David C. Wedge David J. Adams Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
description	Metastatic melanoma is associated with a poor prognosis and understanding the genetic features of metastases may enable better treatment strategies. Here, the authors analyse multiple metastases from individual patients finding high levels of heterogeneity in metastases from different organs.
format	article
author	Roy Rabbie Naser Ansari-Pour Oliver Cast Doreen Lau Francis Scott Sarah J. Welsh Christine Parkinson Leila Khoja Luiza Moore Mark Tullett Kim Wong Ingrid Ferreira Julia M. Martínez Gómez Mitchell Levesque Ferdia A. Gallagher Alejandro Jiménez-Sánchez Laura Riva Martin L. Miller Kieren Allinson Peter J. Campbell Pippa Corrie David C. Wedge David J. Adams
author_facet	Roy Rabbie Naser Ansari-Pour Oliver Cast Doreen Lau Francis Scott Sarah J. Welsh Christine Parkinson Leila Khoja Luiza Moore Mark Tullett Kim Wong Ingrid Ferreira Julia M. Martínez Gómez Mitchell Levesque Ferdia A. Gallagher Alejandro Jiménez-Sánchez Laura Riva Martin L. Miller Kieren Allinson Peter J. Campbell Pippa Corrie David C. Wedge David J. Adams
author_sort	Roy Rabbie
title	Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
title_short	Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
title_full	Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
title_fullStr	Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
title_full_unstemmed	Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
title_sort	multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/88af25cb99664cab9677a9f33b3cdf38
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Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases

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