A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

Cdkn2ab knockout mice develop skin tumours but this phenotype is lost on backcrossing of the mice. Here, the authors describe a genetic variant encompassing Wnt7b that synergises with Cdkn2ab loss and is required for tumour formation in these mice.

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Autores principales:	Paul Krimpenfort, Margriet Snoek, Jan-Paul Lambooij, Ji-Ying Song, Robin van der Weide, Rajith Bhaskaran, Hans Teunissen, David J. Adams, Elzo de Wit, Anton Berns
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88bea2f7c3a344d1b33663cb6275c20c
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spelling	oai:doaj.org-article:88bea2f7c3a344d1b33663cb6275c20c2021-12-02T17:32:10ZA natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis10.1038/s41467-019-09321-82041-1723https://doaj.org/article/88bea2f7c3a344d1b33663cb6275c20c2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09321-8https://doaj.org/toc/2041-1723Cdkn2ab knockout mice develop skin tumours but this phenotype is lost on backcrossing of the mice. Here, the authors describe a genetic variant encompassing Wnt7b that synergises with Cdkn2ab loss and is required for tumour formation in these mice.Paul KrimpenfortMargriet SnoekJan-Paul LambooijJi-Ying SongRobin van der WeideRajith BhaskaranHans TeunissenDavid J. AdamsElzo de WitAnton BernsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul Krimpenfort Margriet Snoek Jan-Paul Lambooij Ji-Ying Song Robin van der Weide Rajith Bhaskaran Hans Teunissen David J. Adams Elzo de Wit Anton Berns A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis
description	Cdkn2ab knockout mice develop skin tumours but this phenotype is lost on backcrossing of the mice. Here, the authors describe a genetic variant encompassing Wnt7b that synergises with Cdkn2ab loss and is required for tumour formation in these mice.
format	article
author	Paul Krimpenfort Margriet Snoek Jan-Paul Lambooij Ji-Ying Song Robin van der Weide Rajith Bhaskaran Hans Teunissen David J. Adams Elzo de Wit Anton Berns
author_facet	Paul Krimpenfort Margriet Snoek Jan-Paul Lambooij Ji-Ying Song Robin van der Weide Rajith Bhaskaran Hans Teunissen David J. Adams Elzo de Wit Anton Berns
author_sort	Paul Krimpenfort
title	A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis
title_short	A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis
title_full	A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis
title_fullStr	A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis
title_full_unstemmed	A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis
title_sort	natural wnt signaling variant potently synergizes with cdkn2ab loss in skin carcinogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/88bea2f7c3a344d1b33663cb6275c20c
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A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

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