Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines.

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Autores principales:	Shreya Mitra, Jeffrey E. Montgomery, Matthew J. Kolar, Gang Li, Kang J. Jeong, Bo Peng, Gregory L. Verdine, Gordon B. Mills, Raymond E. Moellering
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88dae4a0195d4721a84d58ee911ac1ec
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spelling	oai:doaj.org-article:88dae4a0195d4721a84d58ee911ac1ec2021-12-02T15:38:42ZStapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer10.1038/s41467-017-00888-82041-1723https://doaj.org/article/88dae4a0195d4721a84d58ee911ac1ec2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00888-8https://doaj.org/toc/2041-1723The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines.Shreya MitraJeffrey E. MontgomeryMatthew J. KolarGang LiKang J. JeongBo PengGregory L. VerdineGordon B. MillsRaymond E. MoelleringNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shreya Mitra Jeffrey E. Montgomery Matthew J. Kolar Gang Li Kang J. Jeong Bo Peng Gregory L. Verdine Gordon B. Mills Raymond E. Moellering Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
description	The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines.
format	article
author	Shreya Mitra Jeffrey E. Montgomery Matthew J. Kolar Gang Li Kang J. Jeong Bo Peng Gregory L. Verdine Gordon B. Mills Raymond E. Moellering
author_facet	Shreya Mitra Jeffrey E. Montgomery Matthew J. Kolar Gang Li Kang J. Jeong Bo Peng Gregory L. Verdine Gordon B. Mills Raymond E. Moellering
author_sort	Shreya Mitra
title	Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
title_short	Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
title_full	Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
title_fullStr	Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
title_full_unstemmed	Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
title_sort	stapled peptide inhibitors of rab25 target context-specific phenotypes in cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/88dae4a0195d4721a84d58ee911ac1ec
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Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

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