Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines.
Guardado en:
Autores principales: | Shreya Mitra, Jeffrey E. Montgomery, Matthew J. Kolar, Gang Li, Kang J. Jeong, Bo Peng, Gregory L. Verdine, Gordon B. Mills, Raymond E. Moellering |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/88dae4a0195d4721a84d58ee911ac1ec |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold
por: Wei Liang Tan, et al.
Publicado: (2017) -
Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery
por: D. Thean, et al.
Publicado: (2017) -
Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations.
por: Thomas L Joseph, et al.
Publicado: (2012) -
Measuring and estimating shear force of one stapled and one-row multi stapled wood joints
por: Demirel,Samet, et al.
Publicado: (2020) -
Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics
por: Tetsuro Yoshimaru, et al.
Publicado: (2017)