A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating <italic toggle="yes">Salmonella</italic> Infection

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating <italic toggle="yes">Salmonella</italic> Infection

ABSTRACT A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, C...

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Autores principales: Amy T. Y. Yeung, Yoon Ha Choi, Amy H. Y. Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert E. W. Hancock, Gordon Dougan
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
CRISPR
Salmonella
bacteria
genome-wide screen
macrophages
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/88e1f65dbd364ffc8b38e80865afebb5
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