A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating <italic toggle="yes">Salmonella</italic> Infection

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating <italic toggle="yes">Salmonella</italic> Infection

ABSTRACT A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, C...

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Bibliographic Details
Main Authors: Amy T. Y. Yeung, Yoon Ha Choi, Amy H. Y. Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert E. W. Hancock, Gordon Dougan
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
CRISPR
Salmonella
bacteria
genome-wide screen
macrophages
Microbiology
QR1-502
Online Access:https://doaj.org/article/88e1f65dbd364ffc8b38e80865afebb5
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