Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2
Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common forms of arthritis. Limonin (Lim) is extracted from lemons and other citrus fruits. Limonin has been reported to have anti-inflammatory effects, while inflammation is a major cause of OA; thus, we propose that l...
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oai:doaj.org-article:8956271a540e48a58adacfd5ea6f94112021-11-22T01:09:51ZLimonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf21942-099410.1155/2021/7292512https://doaj.org/article/8956271a540e48a58adacfd5ea6f94112021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7292512https://doaj.org/toc/1942-0994Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common forms of arthritis. Limonin (Lim) is extracted from lemons and other citrus fruits. Limonin has been reported to have anti-inflammatory effects, while inflammation is a major cause of OA; thus, we propose that limonin may have a therapeutic effect on OA. In this study, the therapeutic effect of limonin on OA was assessed in chondrocytes in vitro in IL-1β induced OA and in the destabilization of the medial meniscus (DMM) mice in vivo. The Nrf2/HO-1/NF-κB signaling pathway was evaluated to illustrate the working mechanism of limonin on OA in chondrocytes. In this study, it was found that limonin can reduce the level of IL-1β induced proinflammatory cytokines such as INOS, COX-2, PGE2, NO, TNF-α, and IL-6. Limonin can also diminish the biosynthesis of IL-1β-stimulated chondrogenic catabolic enzymes such as MMP13 and ADAMTS5 in chondrocytes. The research on the mechanism study demonstrated that limonin exerts its protective effect on OA through the Nrf2/HO-1/NF-κB signaling pathway. Taken together, the present study shows that limonin may activate the Nrf2/HO-1/NF-κB pathway to alleviate OA, making it a candidate therapeutic agent for OA.Jie JinXinhuang LvBen WangChenghao RenJingtao JiangHongyu ChenXimiao ChenMingbao GuZongyou PanNaifeng TianAimin WuLiaojun SunWeiyang GaoXiangyang WangXiaolei ZhangYaosen WuYifei ZhouHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Cytology QH573-671 |
| spellingShingle |
Cytology QH573-671 Jie Jin Xinhuang Lv Ben Wang Chenghao Ren Jingtao Jiang Hongyu Chen Ximiao Chen Mingbao Gu Zongyou Pan Naifeng Tian Aimin Wu Liaojun Sun Weiyang Gao Xiangyang Wang Xiaolei Zhang Yaosen Wu Yifei Zhou Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2 |
| description |
Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common forms of arthritis. Limonin (Lim) is extracted from lemons and other citrus fruits. Limonin has been reported to have anti-inflammatory effects, while inflammation is a major cause of OA; thus, we propose that limonin may have a therapeutic effect on OA. In this study, the therapeutic effect of limonin on OA was assessed in chondrocytes in vitro in IL-1β induced OA and in the destabilization of the medial meniscus (DMM) mice in vivo. The Nrf2/HO-1/NF-κB signaling pathway was evaluated to illustrate the working mechanism of limonin on OA in chondrocytes. In this study, it was found that limonin can reduce the level of IL-1β induced proinflammatory cytokines such as INOS, COX-2, PGE2, NO, TNF-α, and IL-6. Limonin can also diminish the biosynthesis of IL-1β-stimulated chondrogenic catabolic enzymes such as MMP13 and ADAMTS5 in chondrocytes. The research on the mechanism study demonstrated that limonin exerts its protective effect on OA through the Nrf2/HO-1/NF-κB signaling pathway. Taken together, the present study shows that limonin may activate the Nrf2/HO-1/NF-κB pathway to alleviate OA, making it a candidate therapeutic agent for OA. |
| format |
article |
| author |
Jie Jin Xinhuang Lv Ben Wang Chenghao Ren Jingtao Jiang Hongyu Chen Ximiao Chen Mingbao Gu Zongyou Pan Naifeng Tian Aimin Wu Liaojun Sun Weiyang Gao Xiangyang Wang Xiaolei Zhang Yaosen Wu Yifei Zhou |
| author_facet |
Jie Jin Xinhuang Lv Ben Wang Chenghao Ren Jingtao Jiang Hongyu Chen Ximiao Chen Mingbao Gu Zongyou Pan Naifeng Tian Aimin Wu Liaojun Sun Weiyang Gao Xiangyang Wang Xiaolei Zhang Yaosen Wu Yifei Zhou |
| author_sort |
Jie Jin |
| title |
Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2 |
| title_short |
Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2 |
| title_full |
Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2 |
| title_fullStr |
Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2 |
| title_full_unstemmed |
Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2 |
| title_sort |
limonin inhibits il-1β-induced inflammation and catabolism in chondrocytes and ameliorates osteoarthritis by activating nrf2 |
| publisher |
Hindawi Limited |
| publishDate |
2021 |
| url |
https://doaj.org/article/8956271a540e48a58adacfd5ea6f9411 |
| work_keys_str_mv |
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