Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.

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Detalles Bibliográficos
Autores principales: Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li, Songjie Feng, Yajing Liu, Jianan Li, Wenxia Yu, Yu Zhang, Jia Chen, Qiang Sun, Xingxu Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/8958562bd535472e9a0b1a20d9353429
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https://doaj.org/article/8958562bd535472e9a0b1a20d9353429

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