Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.

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Autores principales:	Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li, Songjie Feng, Yajing Liu, Jianan Li, Wenxia Yu, Yu Zhang, Jia Chen, Qiang Sun, Xingxu Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8958562bd535472e9a0b1a20d9353429
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spelling	oai:doaj.org-article:8958562bd535472e9a0b1a20d93534292021-12-02T16:56:42ZEfficient generation of mouse models of human diseases via ABE- and BE-mediated base editing10.1038/s41467-018-04768-72041-1723https://doaj.org/article/8958562bd535472e9a0b1a20d93534292018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04768-7https://doaj.org/toc/2041-1723CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.Zhen LiuZongyang LuGuang YangShisheng HuangGuanglei LiSongjie FengYajing LiuJianan LiWenxia YuYu ZhangJia ChenQiang SunXingxu HuangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen Liu Zongyang Lu Guang Yang Shisheng Huang Guanglei Li Songjie Feng Yajing Liu Jianan Li Wenxia Yu Yu Zhang Jia Chen Qiang Sun Xingxu Huang Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
description	CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.
format	article
author	Zhen Liu Zongyang Lu Guang Yang Shisheng Huang Guanglei Li Songjie Feng Yajing Liu Jianan Li Wenxia Yu Yu Zhang Jia Chen Qiang Sun Xingxu Huang
author_facet	Zhen Liu Zongyang Lu Guang Yang Shisheng Huang Guanglei Li Songjie Feng Yajing Liu Jianan Li Wenxia Yu Yu Zhang Jia Chen Qiang Sun Xingxu Huang
author_sort	Zhen Liu
title	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_short	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_full	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_fullStr	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_full_unstemmed	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_sort	efficient generation of mouse models of human diseases via abe- and be-mediated base editing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8958562bd535472e9a0b1a20d9353429
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Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

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