Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2018
|
| Subjects: | |
| Online Access: | https://doaj.org/article/8958562bd535472e9a0b1a20d9353429 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|