A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signalling and generate inducible regulatory T cells.
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Nature Portfolio
2017
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oai:doaj.org-article:8966a9c3f97c4921a792b74844b1800f2021-12-02T14:41:58ZA structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells10.1038/s41467-017-01886-62041-1723https://doaj.org/article/8966a9c3f97c4921a792b74844b1800f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01886-6https://doaj.org/toc/2041-1723Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signalling and generate inducible regulatory T cells.Chris J. C. JohnstonDanielle J. SmythRavindra B. KodaliMadeleine P. J. WhiteYvonne HarcusKara J. FilbeyJames P. HewitsonCynthia S. HinckAlasdair IvensAndrea M. KemterAnna O. KildemoesThierry Le BihanDinesh C. SoaresStephen M. AndertonThomas BrennStephen J. WigmoreHannah V. WoodcockRachel C. ChambersAndrew P. HinckHenry J. McSorleyRick M. MaizelsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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DOAJ |
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EN |
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Science Q |
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Science Q Chris J. C. Johnston Danielle J. Smyth Ravindra B. Kodali Madeleine P. J. White Yvonne Harcus Kara J. Filbey James P. Hewitson Cynthia S. Hinck Alasdair Ivens Andrea M. Kemter Anna O. Kildemoes Thierry Le Bihan Dinesh C. Soares Stephen M. Anderton Thomas Brenn Stephen J. Wigmore Hannah V. Woodcock Rachel C. Chambers Andrew P. Hinck Henry J. McSorley Rick M. Maizels A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells |
| description |
Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signalling and generate inducible regulatory T cells. |
| format |
article |
| author |
Chris J. C. Johnston Danielle J. Smyth Ravindra B. Kodali Madeleine P. J. White Yvonne Harcus Kara J. Filbey James P. Hewitson Cynthia S. Hinck Alasdair Ivens Andrea M. Kemter Anna O. Kildemoes Thierry Le Bihan Dinesh C. Soares Stephen M. Anderton Thomas Brenn Stephen J. Wigmore Hannah V. Woodcock Rachel C. Chambers Andrew P. Hinck Henry J. McSorley Rick M. Maizels |
| author_facet |
Chris J. C. Johnston Danielle J. Smyth Ravindra B. Kodali Madeleine P. J. White Yvonne Harcus Kara J. Filbey James P. Hewitson Cynthia S. Hinck Alasdair Ivens Andrea M. Kemter Anna O. Kildemoes Thierry Le Bihan Dinesh C. Soares Stephen M. Anderton Thomas Brenn Stephen J. Wigmore Hannah V. Woodcock Rachel C. Chambers Andrew P. Hinck Henry J. McSorley Rick M. Maizels |
| author_sort |
Chris J. C. Johnston |
| title |
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells |
| title_short |
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells |
| title_full |
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells |
| title_fullStr |
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells |
| title_full_unstemmed |
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells |
| title_sort |
structurally distinct tgf-β mimic from an intestinal helminth parasite potently induces regulatory t cells |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/8966a9c3f97c4921a792b74844b1800f |
| work_keys_str_mv |
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