Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.

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Autores principales:	Amy T. Y. Yeung, Christine Hale, Amy H. Lee, Erin E. Gill, Wendy Bushell, David Parry-Smith, David Goulding, Derek Pickard, Theodoros Roumeliotis, Jyoti Choudhary, Nick Thomson, William C. Skarnes, Gordon Dougan, Robert E. W. Hancock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/896e301f7f054800992a554f5dfd59b5
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spelling	oai:doaj.org-article:896e301f7f054800992a554f5dfd59b52021-12-02T14:40:49ZExploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis10.1038/ncomms150132041-1723https://doaj.org/article/896e301f7f054800992a554f5dfd59b52017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15013https://doaj.org/toc/2041-1723In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.Amy T. Y. YeungChristine HaleAmy H. LeeErin E. GillWendy BushellDavid Parry-SmithDavid GouldingDerek PickardTheodoros RoumeliotisJyoti ChoudharyNick ThomsonWilliam C. SkarnesGordon DouganRobert E. W. HancockNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy T. Y. Yeung Christine Hale Amy H. Lee Erin E. Gill Wendy Bushell David Parry-Smith David Goulding Derek Pickard Theodoros Roumeliotis Jyoti Choudhary Nick Thomson William C. Skarnes Gordon Dougan Robert E. W. Hancock Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
description	In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.
format	article
author	Amy T. Y. Yeung Christine Hale Amy H. Lee Erin E. Gill Wendy Bushell David Parry-Smith David Goulding Derek Pickard Theodoros Roumeliotis Jyoti Choudhary Nick Thomson William C. Skarnes Gordon Dougan Robert E. W. Hancock
author_facet	Amy T. Y. Yeung Christine Hale Amy H. Lee Erin E. Gill Wendy Bushell David Parry-Smith David Goulding Derek Pickard Theodoros Roumeliotis Jyoti Choudhary Nick Thomson William C. Skarnes Gordon Dougan Robert E. W. Hancock
author_sort	Amy T. Y. Yeung
title	Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
title_short	Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
title_full	Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
title_fullStr	Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
title_full_unstemmed	Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
title_sort	exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing chlamydia trachomatis pathogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/896e301f7f054800992a554f5dfd59b5
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Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

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