Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells

Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells

Abstract Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We describe two immunotherapeutics platforms for selective delivery of costimulatory ligands and peptide-HLA (pHLA) to AgS T cells. We engineered and...

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Main Authors: Ronald D. Seidel, Zohra Merazga, Dharma Raj Thapa, Jonathan Soriano, Emily Spaulding, Ahmet S. Vakkasoglu, Paige Ruthardt, Wynona Bautista, Steven N. Quayle, Peter A. Kiener, Simon Low, John F. Ross, Saso Cemerski, Anish Suri, Steven C. Almo, Rodolfo J. Chaparro
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/897c1421d763409b9b5cd4b0353c9706
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https://doaj.org/article/897c1421d763409b9b5cd4b0353c9706

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