Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells

Abstract Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We describe two immunotherapeutics platforms for selective delivery of costimulatory ligands and peptide-HLA (pHLA) to AgS T cells. We engineered and...

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Autores principales:	Ronald D. Seidel, Zohra Merazga, Dharma Raj Thapa, Jonathan Soriano, Emily Spaulding, Ahmet S. Vakkasoglu, Paige Ruthardt, Wynona Bautista, Steven N. Quayle, Peter A. Kiener, Simon Low, John F. Ross, Saso Cemerski, Anish Suri, Steven C. Almo, Rodolfo J. Chaparro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/897c1421d763409b9b5cd4b0353c9706
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spelling	oai:doaj.org-article:897c1421d763409b9b5cd4b0353c97062021-12-02T18:51:15ZPeptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells10.1038/s41598-021-98716-z2045-2322https://doaj.org/article/897c1421d763409b9b5cd4b0353c97062021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98716-zhttps://doaj.org/toc/2045-2322Abstract Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We describe two immunotherapeutics platforms for selective delivery of costimulatory ligands and peptide-HLA (pHLA) to AgS T cells. We engineered and deployed on these platforms an affinity-attenuated variant of interleukin-2, which selectively expands oligoclonal and polyfunctional AgS T cells in vitro and synergizes with CD80 signals for superior proliferation versus peptide stimulation.Ronald D. SeidelZohra MerazgaDharma Raj ThapaJonathan SorianoEmily SpauldingAhmet S. VakkasogluPaige RuthardtWynona BautistaSteven N. QuaylePeter A. KienerSimon LowJohn F. RossSaso CemerskiAnish SuriSteven C. AlmoRodolfo J. ChaparroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ronald D. Seidel Zohra Merazga Dharma Raj Thapa Jonathan Soriano Emily Spaulding Ahmet S. Vakkasoglu Paige Ruthardt Wynona Bautista Steven N. Quayle Peter A. Kiener Simon Low John F. Ross Saso Cemerski Anish Suri Steven C. Almo Rodolfo J. Chaparro Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells
description	Abstract Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We describe two immunotherapeutics platforms for selective delivery of costimulatory ligands and peptide-HLA (pHLA) to AgS T cells. We engineered and deployed on these platforms an affinity-attenuated variant of interleukin-2, which selectively expands oligoclonal and polyfunctional AgS T cells in vitro and synergizes with CD80 signals for superior proliferation versus peptide stimulation.
format	article
author	Ronald D. Seidel Zohra Merazga Dharma Raj Thapa Jonathan Soriano Emily Spaulding Ahmet S. Vakkasoglu Paige Ruthardt Wynona Bautista Steven N. Quayle Peter A. Kiener Simon Low John F. Ross Saso Cemerski Anish Suri Steven C. Almo Rodolfo J. Chaparro
author_facet	Ronald D. Seidel Zohra Merazga Dharma Raj Thapa Jonathan Soriano Emily Spaulding Ahmet S. Vakkasoglu Paige Ruthardt Wynona Bautista Steven N. Quayle Peter A. Kiener Simon Low John F. Ross Saso Cemerski Anish Suri Steven C. Almo Rodolfo J. Chaparro
author_sort	Ronald D. Seidel
title	Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells
title_short	Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells
title_full	Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells
title_fullStr	Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells
title_full_unstemmed	Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells
title_sort	peptide-hla-based immunotherapeutics platforms for direct modulation of antigen-specific t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/897c1421d763409b9b5cd4b0353c9706
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Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells

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