Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells

Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells

Abstract Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We describe two immunotherapeutics platforms for selective delivery of costimulatory ligands and peptide-HLA (pHLA) to AgS T cells. We engineered and...

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Auteurs principaux: Ronald D. Seidel, Zohra Merazga, Dharma Raj Thapa, Jonathan Soriano, Emily Spaulding, Ahmet S. Vakkasoglu, Paige Ruthardt, Wynona Bautista, Steven N. Quayle, Peter A. Kiener, Simon Low, John F. Ross, Saso Cemerski, Anish Suri, Steven C. Almo, Rodolfo J. Chaparro
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/897c1421d763409b9b5cd4b0353c9706
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Internet

https://doaj.org/article/897c1421d763409b9b5cd4b0353c9706

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