A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.

A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.

Obesity and diabetes have strong heritable components, yet the genetic contributions to these diseases remain largely unexplained. In humans, a missense variant in Creb3 regulatory factor (CREBRF) [rs373863828 (p.Arg457Gln); CREBRFR457Q] is strongly associated with increased odds of obesity but decr...

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Autores principales: Jitendra S Kanshana, Polly E Mattila, Michael C Ewing, Ashlee N Wood, Gabriele Schoiswohl, Anna C Meyer, Aneta Kowalski, Samantha L Rosenthal, Sebastien Gingras, Brett A Kaufman, Ray Lu, Daniel E Weeks, Stephen T McGarvey, Ryan L Minster, Nicola L Hawley, Erin E Kershaw
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/89877e3193b84a7a9605cc11de25289c
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https://doaj.org/article/89877e3193b84a7a9605cc11de25289c

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