MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus

In Myxococcus xanthus, directed movement is controlled by pole-to-pole oscillations of the small GTPase MglA and its GAP MglB. Here authors report the complete MglA/MglB structural cycle and uncover that MglA is a three-state GTPase that adopts an atypical GTP-bound state that is refractory to inact...

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Autores principales:	Christian Galicia, Sébastien Lhospice, Paloma Fernández Varela, Stefano Trapani, Wenhua Zhang, Jorge Navaza, Julien Herrou, Tâm Mignot, Jacqueline Cherfils
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/898fe1ad02c946998bee71bbdb3219d7
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spelling	oai:doaj.org-article:898fe1ad02c946998bee71bbdb3219d72021-12-02T17:01:52ZMglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus10.1038/s41467-019-13274-32041-1723https://doaj.org/article/898fe1ad02c946998bee71bbdb3219d72019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13274-3https://doaj.org/toc/2041-1723In Myxococcus xanthus, directed movement is controlled by pole-to-pole oscillations of the small GTPase MglA and its GAP MglB. Here authors report the complete MglA/MglB structural cycle and uncover that MglA is a three-state GTPase that adopts an atypical GTP-bound state that is refractory to inactivation by MglB.Christian GaliciaSébastien LhospicePaloma Fernández VarelaStefano TrapaniWenhua ZhangJorge NavazaJulien HerrouTâm MignotJacqueline CherfilsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian Galicia Sébastien Lhospice Paloma Fernández Varela Stefano Trapani Wenhua Zhang Jorge Navaza Julien Herrou Tâm Mignot Jacqueline Cherfils MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus
description	In Myxococcus xanthus, directed movement is controlled by pole-to-pole oscillations of the small GTPase MglA and its GAP MglB. Here authors report the complete MglA/MglB structural cycle and uncover that MglA is a three-state GTPase that adopts an atypical GTP-bound state that is refractory to inactivation by MglB.
format	article
author	Christian Galicia Sébastien Lhospice Paloma Fernández Varela Stefano Trapani Wenhua Zhang Jorge Navaza Julien Herrou Tâm Mignot Jacqueline Cherfils
author_facet	Christian Galicia Sébastien Lhospice Paloma Fernández Varela Stefano Trapani Wenhua Zhang Jorge Navaza Julien Herrou Tâm Mignot Jacqueline Cherfils
author_sort	Christian Galicia
title	MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus
title_short	MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus
title_full	MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus
title_fullStr	MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus
title_full_unstemmed	MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus
title_sort	mgla functions as a three-state gtpase to control movement reversals of myxococcus xanthus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/898fe1ad02c946998bee71bbdb3219d7
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MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus

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