Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice

Abstract Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with ApcMin/+ mice to obtain ma...

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Autores principales: Lorenzo M. Fernandes, Ahmed Al-Dwairi, Rosalia C. M. Simmen, Meera Marji, Dustin M. Brown, Sarah W. Jewell, Frank A. Simmen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/899beda0f140402686c9d2bb53f53cc2
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