The Transcriptional Complex Sp1/KMT2A by Up-Regulating Restrictive Element 1 Silencing Transcription Factor Accelerates Methylmercury-Induced Cell Death in Motor Neuron-Like NSC34 Cells Overexpressing SOD1-G93A
Methylmercury (MeHg) exposure has been related to amyotrophic lateral sclerosis (ALS) pathogenesis and molecular mechanisms of its neurotoxicity has been associated to an overexpression of the Restrictive Element 1 Silencing Transcription factor (REST). Herein, we evaluated the possibility that MeHg...
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Auteurs principaux: | Natascia Guida, Luca Sanguigno, Luigi Mascolo, Lucrezia Calabrese, Angelo Serani, Pasquale Molinaro, C. Geoffrey Lau, Lucio Annunziato, Luigi Formisano |
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Format: | article |
Langue: | EN |
Publié: |
Frontiers Media S.A.
2021
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Sujets: | |
Accès en ligne: | https://doaj.org/article/89a302f1e8e84e34bd6a9666029f77d1 |
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