Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies

Zhang et al. present the cryo-EM structure of ATP-binding cassette transporters ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3.3 Å resolution. This study provides structural insights into the transport cycle and potential epitopes for therapeutic interventions that co...

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Autores principales:	Hanzhi Zhang, Ching-Shin Huang, Xinchao Yu, Jonas Lee, Amit Vaish, Qing Chen, Mingyue Zhou, Zhulun Wang, Xiaoshan Min
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f3
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spelling	oai:doaj.org-article:89adae28264f40d7b90ec8bef59c63f32021-12-02T15:38:22ZCryo-EM structure of ABCG5/G8 in complex with modulating antibodies10.1038/s42003-021-02039-82399-3642https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f32021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02039-8https://doaj.org/toc/2399-3642Zhang et al. present the cryo-EM structure of ATP-binding cassette transporters ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3.3 Å resolution. This study provides structural insights into the transport cycle and potential epitopes for therapeutic interventions that control cholesterol homeostasis.Hanzhi ZhangChing-Shin HuangXinchao YuJonas LeeAmit VaishQing ChenMingyue ZhouZhulun WangXiaoshan MinNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hanzhi Zhang Ching-Shin Huang Xinchao Yu Jonas Lee Amit Vaish Qing Chen Mingyue Zhou Zhulun Wang Xiaoshan Min Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
description	Zhang et al. present the cryo-EM structure of ATP-binding cassette transporters ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3.3 Å resolution. This study provides structural insights into the transport cycle and potential epitopes for therapeutic interventions that control cholesterol homeostasis.
format	article
author	Hanzhi Zhang Ching-Shin Huang Xinchao Yu Jonas Lee Amit Vaish Qing Chen Mingyue Zhou Zhulun Wang Xiaoshan Min
author_facet	Hanzhi Zhang Ching-Shin Huang Xinchao Yu Jonas Lee Amit Vaish Qing Chen Mingyue Zhou Zhulun Wang Xiaoshan Min
author_sort	Hanzhi Zhang
title	Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
title_short	Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
title_full	Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
title_fullStr	Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
title_full_unstemmed	Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
title_sort	cryo-em structure of abcg5/g8 in complex with modulating antibodies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f3
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Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies

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