Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis

Abstract Biological therapies have dramatically improved the therapeutic landscape of psoriatic arthritis (PsA); however, 40–50% of patients are primary non-responders with response rates declining significantly with each successive biological therapy. Therefore, there is a pressing need to develop...

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Auteurs principaux: Sara Rahmati, Darren D. O’Rielly, Quan Li, Dianne Codner, Amanda Dohey, Kari Jenkins, Igor Jurisica, Dafna D. Gladman, Vinod Chandran, Proton Rahman
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/89afa7b431d842f397da1b39a9b64a04
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