ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
The ubiquitin-like modifier ISG15 exerts post-translational protein regulation through ISGylation. Here, the authors show that ISGylation is necessary for pancreatic cancer stem cell self-renewal and tumourigenesis by supporting the recycling of non-functional mitochondria.
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2020
|
| Subjects: | |
| Online Access: | https://doaj.org/article/89c3ab82d8814e75bb09a84a79555d89 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|