STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap

The perinuclear actin cap determines nuclear morphology but its regulation is currently poorly understood. Here, the authors find that an activator of the Rac1 GTPase, STEF/TIAM2, localises to the nuclear envelope and contributes to perinuclear actin and myosin tension, which in turn regulates the a...

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Autores principales:	Anna Woroniuk, Andrew Porter, Gavin White, Daniel T. Newman, Zoi Diamantopoulou, Thomas Waring, Claire Rooney, Douglas Strathdee, Daniel J. Marston, Klaus M. Hahn, Owen J. Sansom, Tobias Zech, Angeliki Malliri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a03de08b5bf41b383217440b51867d5
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spelling	oai:doaj.org-article:8a03de08b5bf41b383217440b51867d52021-12-02T14:39:07ZSTEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap10.1038/s41467-018-04404-42041-1723https://doaj.org/article/8a03de08b5bf41b383217440b51867d52018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04404-4https://doaj.org/toc/2041-1723The perinuclear actin cap determines nuclear morphology but its regulation is currently poorly understood. Here, the authors find that an activator of the Rac1 GTPase, STEF/TIAM2, localises to the nuclear envelope and contributes to perinuclear actin and myosin tension, which in turn regulates the actin cap.Anna WoroniukAndrew PorterGavin WhiteDaniel T. NewmanZoi DiamantopoulouThomas WaringClaire RooneyDouglas StrathdeeDaniel J. MarstonKlaus M. HahnOwen J. SansomTobias ZechAngeliki MalliriNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna Woroniuk Andrew Porter Gavin White Daniel T. Newman Zoi Diamantopoulou Thomas Waring Claire Rooney Douglas Strathdee Daniel J. Marston Klaus M. Hahn Owen J. Sansom Tobias Zech Angeliki Malliri STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
description	The perinuclear actin cap determines nuclear morphology but its regulation is currently poorly understood. Here, the authors find that an activator of the Rac1 GTPase, STEF/TIAM2, localises to the nuclear envelope and contributes to perinuclear actin and myosin tension, which in turn regulates the actin cap.
format	article
author	Anna Woroniuk Andrew Porter Gavin White Daniel T. Newman Zoi Diamantopoulou Thomas Waring Claire Rooney Douglas Strathdee Daniel J. Marston Klaus M. Hahn Owen J. Sansom Tobias Zech Angeliki Malliri
author_facet	Anna Woroniuk Andrew Porter Gavin White Daniel T. Newman Zoi Diamantopoulou Thomas Waring Claire Rooney Douglas Strathdee Daniel J. Marston Klaus M. Hahn Owen J. Sansom Tobias Zech Angeliki Malliri
author_sort	Anna Woroniuk
title	STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
title_short	STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
title_full	STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
title_fullStr	STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
title_full_unstemmed	STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
title_sort	stef/tiam2-mediated rac1 activity at the nuclear envelope regulates the perinuclear actin cap
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8a03de08b5bf41b383217440b51867d5
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STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap

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