Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

Antibodies that target the N-terminal domain (NTD) of the MERS-CoV spike remain poorly characterized. Here, Zhou et al. report the structural and functional analysis of the NTD-targeting mAb 7D10 and show that it synergizes with antibodies targeting the receptor-binding domain against different MERS...

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Autores principales: Haixia Zhou, Yingzhu Chen, Shuyuan Zhang, Peihua Niu, Kun Qin, Wenxu Jia, Baoying Huang, Senyan Zhang, Jun Lan, Linqi Zhang, Wenjie Tan, Xinquan Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/8a133a47d4394d95889e6dc384e4b385
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spelling oai:doaj.org-article:8a133a47d4394d95889e6dc384e4b3852021-12-02T16:57:46ZStructural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein10.1038/s41467-019-10897-42041-1723https://doaj.org/article/8a133a47d4394d95889e6dc384e4b3852019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10897-4https://doaj.org/toc/2041-1723Antibodies that target the N-terminal domain (NTD) of the MERS-CoV spike remain poorly characterized. Here, Zhou et al. report the structural and functional analysis of the NTD-targeting mAb 7D10 and show that it synergizes with antibodies targeting the receptor-binding domain against different MERS-CoV strains.Haixia ZhouYingzhu ChenShuyuan ZhangPeihua NiuKun QinWenxu JiaBaoying HuangSenyan ZhangJun LanLinqi ZhangWenjie TanXinquan WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Haixia Zhou
Yingzhu Chen
Shuyuan Zhang
Peihua Niu
Kun Qin
Wenxu Jia
Baoying Huang
Senyan Zhang
Jun Lan
Linqi Zhang
Wenjie Tan
Xinquan Wang
Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
description Antibodies that target the N-terminal domain (NTD) of the MERS-CoV spike remain poorly characterized. Here, Zhou et al. report the structural and functional analysis of the NTD-targeting mAb 7D10 and show that it synergizes with antibodies targeting the receptor-binding domain against different MERS-CoV strains.
format article
author Haixia Zhou
Yingzhu Chen
Shuyuan Zhang
Peihua Niu
Kun Qin
Wenxu Jia
Baoying Huang
Senyan Zhang
Jun Lan
Linqi Zhang
Wenjie Tan
Xinquan Wang
author_facet Haixia Zhou
Yingzhu Chen
Shuyuan Zhang
Peihua Niu
Kun Qin
Wenxu Jia
Baoying Huang
Senyan Zhang
Jun Lan
Linqi Zhang
Wenjie Tan
Xinquan Wang
author_sort Haixia Zhou
title Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
title_short Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
title_full Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
title_fullStr Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
title_full_unstemmed Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
title_sort structural definition of a neutralization epitope on the n-terminal domain of mers-cov spike glycoprotein
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/8a133a47d4394d95889e6dc384e4b385
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