Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.

Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.

<h4>Objective</h4>Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission. Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocyte...

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Bibliographic Details
Main Authors: Martijn J Stax, Marloes A Naarding, Michael W T Tanck, Susanne Lindquist, Olle Hernell, Robert Lyle, Per Brandtzaeg, Merete Eggesbø, Georgios Pollakis, William A Paxton
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/8a173af89c9c443c88795ef61dffd475
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https://doaj.org/article/8a173af89c9c443c88795ef61dffd475

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