Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.

<h4>Objective</h4>Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission. Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocyte...

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Autores principales:	Martijn J Stax, Marloes A Naarding, Michael W T Tanck, Susanne Lindquist, Olle Hernell, Robert Lyle, Per Brandtzaeg, Merete Eggesbø, Georgios Pollakis, William A Paxton
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a173af89c9c443c88795ef61dffd475
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spelling	oai:doaj.org-article:8a173af89c9c443c88795ef61dffd4752021-11-18T06:58:06ZBinding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.1932-620310.1371/journal.pone.0017316https://doaj.org/article/8a173af89c9c443c88795ef61dffd4752011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21386960/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission. Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocytes with HIV-1. Objective was to study variation in DC-SIGN binding properties and the relation between DC-SIGN binding capacity of milk and BSSL gene polymorphisms.<h4>Study design</h4>ELISA and PCR were used to study DC-SIGN binding properties and BSSL exon 11 size variation for human milk derived from 269 different mothers distributed over 4 geographical regions.<h4>Results</h4>DC-SIGN binding properties were highly variable for milks derived from different mothers and between samplings from different geographical regions. Differences in DC-SIGN binding were correlated with a genetic polymorphism in BSSL which is related to the number of 11 amino acid repeats at the C-terminus of the protein.<h4>Conclusion</h4>The observed variation in DC-SIGN binding properties among milk samples may have implications for the risk of mucosal transmission of pathogens during breastfeeding.Martijn J StaxMarloes A NaardingMichael W T TanckSusanne LindquistOlle HernellRobert LylePer BrandtzaegMerete EggesbøGeorgios PollakisWilliam A PaxtonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17316 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martijn J Stax Marloes A Naarding Michael W T Tanck Susanne Lindquist Olle Hernell Robert Lyle Per Brandtzaeg Merete Eggesbø Georgios Pollakis William A Paxton Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.
description	<h4>Objective</h4>Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission. Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocytes with HIV-1. Objective was to study variation in DC-SIGN binding properties and the relation between DC-SIGN binding capacity of milk and BSSL gene polymorphisms.<h4>Study design</h4>ELISA and PCR were used to study DC-SIGN binding properties and BSSL exon 11 size variation for human milk derived from 269 different mothers distributed over 4 geographical regions.<h4>Results</h4>DC-SIGN binding properties were highly variable for milks derived from different mothers and between samplings from different geographical regions. Differences in DC-SIGN binding were correlated with a genetic polymorphism in BSSL which is related to the number of 11 amino acid repeats at the C-terminus of the protein.<h4>Conclusion</h4>The observed variation in DC-SIGN binding properties among milk samples may have implications for the risk of mucosal transmission of pathogens during breastfeeding.
format	article
author	Martijn J Stax Marloes A Naarding Michael W T Tanck Susanne Lindquist Olle Hernell Robert Lyle Per Brandtzaeg Merete Eggesbø Georgios Pollakis William A Paxton
author_facet	Martijn J Stax Marloes A Naarding Michael W T Tanck Susanne Lindquist Olle Hernell Robert Lyle Per Brandtzaeg Merete Eggesbø Georgios Pollakis William A Paxton
author_sort	Martijn J Stax
title	Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.
title_short	Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.
title_full	Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.
title_fullStr	Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.
title_full_unstemmed	Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.
title_sort	binding of human milk to pathogen receptor dc-sign varies with bile salt-stimulated lipase (bssl) gene polymorphism.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/8a173af89c9c443c88795ef61dffd475
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Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.

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