Transcriptional effects of copy number alterations in a large set of human cancers

Copy number alterations (CNAs) can drive tumor progression in cancer by altering gene expression levels, but transcriptional adaption can skew CNA impact. Here, the authors present transcriptional adaptation to CNA (TACNA) profiling; a tool to extract the transcriptional effect of CNAs from expressi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Arkajyoti Bhattacharya, Rico D. Bense, Carlos G. Urzúa-Traslaviña, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/8a30eeb79fbb4839b329f70a9a9b4653
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:8a30eeb79fbb4839b329f70a9a9b4653
record_format	dspace
spelling	oai:doaj.org-article:8a30eeb79fbb4839b329f70a9a9b46532021-12-02T16:56:34ZTranscriptional effects of copy number alterations in a large set of human cancers10.1038/s41467-020-14605-52041-1723https://doaj.org/article/8a30eeb79fbb4839b329f70a9a9b46532020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14605-5https://doaj.org/toc/2041-1723Copy number alterations (CNAs) can drive tumor progression in cancer by altering gene expression levels, but transcriptional adaption can skew CNA impact. Here, the authors present transcriptional adaptation to CNA (TACNA) profiling; a tool to extract the transcriptional effect of CNAs from expression data without requiring paired CNA profiles.Arkajyoti BhattacharyaRico D. BenseCarlos G. Urzúa-TraslaviñaElisabeth G. E. de VriesMarcel A. T. M. van VugtRudolf S. N. FehrmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arkajyoti Bhattacharya Rico D. Bense Carlos G. Urzúa-Traslaviña Elisabeth G. E. de Vries Marcel A. T. M. van Vugt Rudolf S. N. Fehrmann Transcriptional effects of copy number alterations in a large set of human cancers
description	Copy number alterations (CNAs) can drive tumor progression in cancer by altering gene expression levels, but transcriptional adaption can skew CNA impact. Here, the authors present transcriptional adaptation to CNA (TACNA) profiling; a tool to extract the transcriptional effect of CNAs from expression data without requiring paired CNA profiles.
format	article
author	Arkajyoti Bhattacharya Rico D. Bense Carlos G. Urzúa-Traslaviña Elisabeth G. E. de Vries Marcel A. T. M. van Vugt Rudolf S. N. Fehrmann
author_facet	Arkajyoti Bhattacharya Rico D. Bense Carlos G. Urzúa-Traslaviña Elisabeth G. E. de Vries Marcel A. T. M. van Vugt Rudolf S. N. Fehrmann
author_sort	Arkajyoti Bhattacharya
title	Transcriptional effects of copy number alterations in a large set of human cancers
title_short	Transcriptional effects of copy number alterations in a large set of human cancers
title_full	Transcriptional effects of copy number alterations in a large set of human cancers
title_fullStr	Transcriptional effects of copy number alterations in a large set of human cancers
title_full_unstemmed	Transcriptional effects of copy number alterations in a large set of human cancers
title_sort	transcriptional effects of copy number alterations in a large set of human cancers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8a30eeb79fbb4839b329f70a9a9b4653
work_keys_str_mv	AT arkajyotibhattacharya transcriptionaleffectsofcopynumberalterationsinalargesetofhumancancers AT ricodbense transcriptionaleffectsofcopynumberalterationsinalargesetofhumancancers AT carlosgurzuatraslavina transcriptionaleffectsofcopynumberalterationsinalargesetofhumancancers AT elisabethgedevries transcriptionaleffectsofcopynumberalterationsinalargesetofhumancancers AT marcelatmvanvugt transcriptionaleffectsofcopynumberalterationsinalargesetofhumancancers AT rudolfsnfehrmann transcriptionaleffectsofcopynumberalterationsinalargesetofhumancancers
_version_	1718382810349174784

Transcriptional effects of copy number alterations in a large set of human cancers

Similar Items