Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis

Abstract Senescent vascular cells are detected in atherosclerotic lesion, and its involvement in the development of atherosclerosis has been revealed; however, whether and the mechanism by which endothelial cell (EC) senescence is causally implicated in atherosclerosis remains unclear. We here inves...

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Bibliographic Details
Main Authors: Sakiko Honda, Koji Ikeda, Ryota Urata, Ekura Yamazaki, Noriaki Emoto, Satoaki Matoba
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/8a34ecd3f6314f959460d8035c051b9c
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