Epigenetic landscapes explain partially reprogrammed cells and identify key reprogramming genes.

A common metaphor for describing development is a rugged "epigenetic landscape" where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly constructing epigenetic landscapes that combines genomic data wi...

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Bibliographic Details
Main Authors: Alex H Lang, Hu Li, James J Collins, Pankaj Mehta
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Online Access:https://doaj.org/article/8a4fd51465244b7eabf47a56bd2bd5d2
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