Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

Inhibiting TGF-β1 to increase immune responses against tumors bears the risk of tumor-promoting toxicity. Here the authors show that selectively blocking TGF-β1 produced by immunosuppressive cells is feasible with anti-GARP:TGF-β1 antibodies and improves the efficacy of PD-1 blockade immunotherapy....

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Autores principales:	Grégoire de Streel, Charlotte Bertrand, Nicolas Chalon, Stéphanie Liénart, Orian Bricard, Sara Lecomte, Julien Devreux, Mélanie Gaignage, Gitte De Boeck, Lore Mariën, Inge Van De Walle, Bas van der Woning, Michael Saunders, Hans de Haard, Elien Vermeersch, Wim Maes, Hans Deckmyn, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a55d3ad04c940c5ae3df3fd9a81d1dc
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spelling	oai:doaj.org-article:8a55d3ad04c940c5ae3df3fd9a81d1dc2021-12-02T18:03:07ZSelective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer10.1038/s41467-020-17811-32041-1723https://doaj.org/article/8a55d3ad04c940c5ae3df3fd9a81d1dc2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17811-3https://doaj.org/toc/2041-1723Inhibiting TGF-β1 to increase immune responses against tumors bears the risk of tumor-promoting toxicity. Here the authors show that selectively blocking TGF-β1 produced by immunosuppressive cells is feasible with anti-GARP:TGF-β1 antibodies and improves the efficacy of PD-1 blockade immunotherapy.Grégoire de StreelCharlotte BertrandNicolas ChalonStéphanie LiénartOrian BricardSara LecomteJulien DevreuxMélanie GaignageGitte De BoeckLore MariënInge Van De WalleBas van der WoningMichael SaundersHans de HaardElien VermeerschWim MaesHans DeckmynPierre G. CoulieNicolas van BarenSophie LucasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Grégoire de Streel Charlotte Bertrand Nicolas Chalon Stéphanie Liénart Orian Bricard Sara Lecomte Julien Devreux Mélanie Gaignage Gitte De Boeck Lore Mariën Inge Van De Walle Bas van der Woning Michael Saunders Hans de Haard Elien Vermeersch Wim Maes Hans Deckmyn Pierre G. Coulie Nicolas van Baren Sophie Lucas Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
description	Inhibiting TGF-β1 to increase immune responses against tumors bears the risk of tumor-promoting toxicity. Here the authors show that selectively blocking TGF-β1 produced by immunosuppressive cells is feasible with anti-GARP:TGF-β1 antibodies and improves the efficacy of PD-1 blockade immunotherapy.
format	article
author	Grégoire de Streel Charlotte Bertrand Nicolas Chalon Stéphanie Liénart Orian Bricard Sara Lecomte Julien Devreux Mélanie Gaignage Gitte De Boeck Lore Mariën Inge Van De Walle Bas van der Woning Michael Saunders Hans de Haard Elien Vermeersch Wim Maes Hans Deckmyn Pierre G. Coulie Nicolas van Baren Sophie Lucas
author_facet	Grégoire de Streel Charlotte Bertrand Nicolas Chalon Stéphanie Liénart Orian Bricard Sara Lecomte Julien Devreux Mélanie Gaignage Gitte De Boeck Lore Mariën Inge Van De Walle Bas van der Woning Michael Saunders Hans de Haard Elien Vermeersch Wim Maes Hans Deckmyn Pierre G. Coulie Nicolas van Baren Sophie Lucas
author_sort	Grégoire de Streel
title	Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
title_short	Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
title_full	Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
title_fullStr	Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
title_full_unstemmed	Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
title_sort	selective inhibition of tgf-β1 produced by garp-expressing tregs overcomes resistance to pd-1/pd-l1 blockade in cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8a55d3ad04c940c5ae3df3fd9a81d1dc
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Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

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