Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis.

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Auteurs principaux: Guillermo Rodríguez-Hernández, Friederike V. Opitz, Pilar Delgado, Carolin Walter, Ángel F. Álvarez-Prado, Inés González-Herrero, Franziska Auer, Ute Fischer, Stefan Janssen, Christoph Bartenhagen, Javier Raboso-Gallego, Ana Casado-García, Alberto Orfao, Oscar Blanco, Diego Alonso-López, Javier De Las Rivas, Sara González de Tena-Dávila, Markus Müschen, Martin Dugas, Francisco Javier García Criado, María Begoña García Cenador, Carolina Vicente-Dueñas, Julia Hauer, Almudena R. Ramiro, Isidro Sanchez-Garcia, Arndt Borkhardt
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/8a5af14a1ec34d24b634ebc17db69869
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Internet

https://doaj.org/article/8a5af14a1ec34d24b634ebc17db69869

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