Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID
Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis.
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Nature Portfolio
2019
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oai:doaj.org-article:8a5af14a1ec34d24b634ebc17db698692021-12-02T17:01:38ZInfectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID10.1038/s41467-019-13570-y2041-1723https://doaj.org/article/8a5af14a1ec34d24b634ebc17db698692019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13570-yhttps://doaj.org/toc/2041-1723Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis.Guillermo Rodríguez-HernándezFriederike V. OpitzPilar DelgadoCarolin WalterÁngel F. Álvarez-PradoInés González-HerreroFranziska AuerUte FischerStefan JanssenChristoph BartenhagenJavier Raboso-GallegoAna Casado-GarcíaAlberto OrfaoOscar BlancoDiego Alonso-LópezJavier De Las RivasSara González de Tena-DávilaMarkus MüschenMartin DugasFrancisco Javier García CriadoMaría Begoña García CenadorCarolina Vicente-DueñasJulia HauerAlmudena R. RamiroIsidro Sanchez-GarciaArndt BorkhardtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Guillermo Rodríguez-Hernández Friederike V. Opitz Pilar Delgado Carolin Walter Ángel F. Álvarez-Prado Inés González-Herrero Franziska Auer Ute Fischer Stefan Janssen Christoph Bartenhagen Javier Raboso-Gallego Ana Casado-García Alberto Orfao Oscar Blanco Diego Alonso-López Javier De Las Rivas Sara González de Tena-Dávila Markus Müschen Martin Dugas Francisco Javier García Criado María Begoña García Cenador Carolina Vicente-Dueñas Julia Hauer Almudena R. Ramiro Isidro Sanchez-Garcia Arndt Borkhardt Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID |
| description |
Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis. |
| format |
article |
| author |
Guillermo Rodríguez-Hernández Friederike V. Opitz Pilar Delgado Carolin Walter Ángel F. Álvarez-Prado Inés González-Herrero Franziska Auer Ute Fischer Stefan Janssen Christoph Bartenhagen Javier Raboso-Gallego Ana Casado-García Alberto Orfao Oscar Blanco Diego Alonso-López Javier De Las Rivas Sara González de Tena-Dávila Markus Müschen Martin Dugas Francisco Javier García Criado María Begoña García Cenador Carolina Vicente-Dueñas Julia Hauer Almudena R. Ramiro Isidro Sanchez-Garcia Arndt Borkhardt |
| author_facet |
Guillermo Rodríguez-Hernández Friederike V. Opitz Pilar Delgado Carolin Walter Ángel F. Álvarez-Prado Inés González-Herrero Franziska Auer Ute Fischer Stefan Janssen Christoph Bartenhagen Javier Raboso-Gallego Ana Casado-García Alberto Orfao Oscar Blanco Diego Alonso-López Javier De Las Rivas Sara González de Tena-Dávila Markus Müschen Martin Dugas Francisco Javier García Criado María Begoña García Cenador Carolina Vicente-Dueñas Julia Hauer Almudena R. Ramiro Isidro Sanchez-Garcia Arndt Borkhardt |
| author_sort |
Guillermo Rodríguez-Hernández |
| title |
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID |
| title_short |
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID |
| title_full |
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID |
| title_fullStr |
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID |
| title_full_unstemmed |
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID |
| title_sort |
infectious stimuli promote malignant b-cell acute lymphoblastic leukemia in the absence of aid |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/8a5af14a1ec34d24b634ebc17db69869 |
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