Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tis...
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Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
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Accès en ligne: | https://doaj.org/article/8a7df5ad28dd4b319f2772959888bbcb |
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