Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tis...

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Autores principales:	Youngmin A. Lee, Luke A. Noon, Kemal M. Akat, Maria D. Ybanez, Ting-Fang Lee, Marie-Luise Berres, Naoto Fujiwara, Nicolas Goossens, Hsin-I Chou, Fatemeh P. Parvin-Nejad, Bilon Khambu, Elisabeth G. M. Kramer, Ronald Gordon, Cathie Pfleger, Doris Germain, Gareth R. John, Kirk N. Campbell, Zhenyu Yue, Xiao-Ming Yin, Ana Maria Cuervo, Mark J. Czaja, M. Isabel Fiel, Yujin Hoshida, Scott L. Friedman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a7df5ad28dd4b319f2772959888bbcb
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spelling	oai:doaj.org-article:8a7df5ad28dd4b319f2772959888bbcb2021-12-02T14:38:48ZAutophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap10.1038/s41467-018-07338-z2041-1723https://doaj.org/article/8a7df5ad28dd4b319f2772959888bbcb2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07338-zhttps://doaj.org/toc/2041-1723Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tissues.Youngmin A. LeeLuke A. NoonKemal M. AkatMaria D. YbanezTing-Fang LeeMarie-Luise BerresNaoto FujiwaraNicolas GoossensHsin-I ChouFatemeh P. Parvin-NejadBilon KhambuElisabeth G. M. KramerRonald GordonCathie PflegerDoris GermainGareth R. JohnKirk N. CampbellZhenyu YueXiao-Ming YinAna Maria CuervoMark J. CzajaM. Isabel FielYujin HoshidaScott L. FriedmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Youngmin A. Lee Luke A. Noon Kemal M. Akat Maria D. Ybanez Ting-Fang Lee Marie-Luise Berres Naoto Fujiwara Nicolas Goossens Hsin-I Chou Fatemeh P. Parvin-Nejad Bilon Khambu Elisabeth G. M. Kramer Ronald Gordon Cathie Pfleger Doris Germain Gareth R. John Kirk N. Campbell Zhenyu Yue Xiao-Ming Yin Ana Maria Cuervo Mark J. Czaja M. Isabel Fiel Yujin Hoshida Scott L. Friedman Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
description	Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tissues.
format	article
author	Youngmin A. Lee Luke A. Noon Kemal M. Akat Maria D. Ybanez Ting-Fang Lee Marie-Luise Berres Naoto Fujiwara Nicolas Goossens Hsin-I Chou Fatemeh P. Parvin-Nejad Bilon Khambu Elisabeth G. M. Kramer Ronald Gordon Cathie Pfleger Doris Germain Gareth R. John Kirk N. Campbell Zhenyu Yue Xiao-Ming Yin Ana Maria Cuervo Mark J. Czaja M. Isabel Fiel Yujin Hoshida Scott L. Friedman
author_facet	Youngmin A. Lee Luke A. Noon Kemal M. Akat Maria D. Ybanez Ting-Fang Lee Marie-Luise Berres Naoto Fujiwara Nicolas Goossens Hsin-I Chou Fatemeh P. Parvin-Nejad Bilon Khambu Elisabeth G. M. Kramer Ronald Gordon Cathie Pfleger Doris Germain Gareth R. John Kirk N. Campbell Zhenyu Yue Xiao-Ming Yin Ana Maria Cuervo Mark J. Czaja M. Isabel Fiel Yujin Hoshida Scott L. Friedman
author_sort	Youngmin A. Lee
title	Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
title_short	Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
title_full	Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
title_fullStr	Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
title_full_unstemmed	Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
title_sort	autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of yap
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8a7df5ad28dd4b319f2772959888bbcb
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Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

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