Bonsai Gelsolin Survives Heat Induced Denaturation by Forming β-Amyloids which Leach Out Functional Monomer

Abstract Here, we report that minimal functional gelsolin i.e. fragment 28–161 can display F-actin depolymerizing property even after heating the protein to 80 °C. Small angle X-ray scattering (SAXS) data analysis confirmed that under Ca2+-free conditions, 28–161 associates into monomer to dimer and...

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Auteurs principaux: Maulik D. Badmalia, Pankaj Sharma, Shiv Pratap Singh Yadav, Shikha Singh, Neeraj Khatri, Renu Garg, Ashish
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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R
Q
Accès en ligne:https://doaj.org/article/8ad1e21c804f41dca963fbf023acebc8
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