Combinatorial Regimen of Carbamazepine and Imipramine Exhibits Synergism against Grandmal Epilepsy in Rats: Inhibition of Pro-Inflammatory Cytokines and PI3K/Akt/mTOR Signaling Pathway

Combinatorial Regimen of Carbamazepine and Imipramine Exhibits Synergism against Grandmal Epilepsy in Rats: Inhibition of Pro-Inflammatory Cytokines and PI3K/Akt/mTOR Signaling Pathway

Epilepsy is a neurodegenerative disorder that causes recurring seizures. Thirty-five percent of patients remain refractory, with a higher prevalence of depression. We investigated the anticonvulsant efficacy of carbamazepine (CBZ; 20 and 50 mg/kg), imipramine (IMI; 10 and 20 mg/kg) alone, and as a l...

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Autores principales: Faheem Hyder Pottoo, Mohammed Salahuddin, Firdos Alam Khan, Marwa Abdullah AL Dhamen, Walaa Jafar Alsaeed, Mohamed S. Gomaa, Chittibabu Vatte, Mohammad N. Alomary
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
epilepsy
neurodegenerative disorder
seizures
PI3K/Akt/mTOR signaling
inflammation
cooperative binding
Medicine
R
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/8adfdae47fab48f5bff0c801efa5ed32
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https://doaj.org/article/8adfdae47fab48f5bff0c801efa5ed32

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