Natural SINEUP RNAs in Autism Spectrum Disorders: RAB11B-AS1 Dysregulation in a Neuronal CHD8 Suppression Model Leads to RAB11B Protein Increase

Natural SINEUP RNAs in Autism Spectrum Disorders: RAB11B-AS1 Dysregulation in a Neuronal CHD8 Suppression Model Leads to RAB11B Protein Increase

CHD8 represents one of the highest confidence genetic risk factors implied in Autism Spectrum Disorders, with most mutations leading to CHD8 haploinsufficiency and the insurgence of specific phenotypes, such as macrocephaly, facial dysmorphisms, intellectual disability, and gastrointestinal complain...

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Autores principales: Giulia Zarantonello, Michele Arnoldi, Michele Filosi, Toma Tebaldi, Giovanni Spirito, Anna Barbieri, Stefano Gustincich, Remo Sanges, Enrico Domenici, Francesca Di Leva, Marta Biagioli
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
autism spectrum disorders (ASD)
CHD8
lncRNA
natural antisense transcript (NAT)
SINEUP
post-transcriptional regulation
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/8aebf72ce5014c2fba54cc8dcf920ad9
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https://doaj.org/article/8aebf72ce5014c2fba54cc8dcf920ad9

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